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KMID : 1137020130240020135
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Journal of Gynecologic Oncology
2013 Volume.24 No. 2 p.135 ~ p.140
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Reproductive factors for ovarian cancer in southern Chinese women
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Pasalich Maria
Su Dada
Binns Colin W.
Lee Andy H.
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Abstract
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Objective: To investigate the association between reproductive factors and the risk of ovarian cancer among southern Chinese women.
Methods: A hospital-based case-control study was undertaken in Guangzhou, Guangdong Province, between 2006 and 2008. A structured questionnaire was used to obtain information on parity, oral contraceptive use and other reproductive factors in a sample of 500 incident ovarian cancer patients and 500 controls (mean age, 59 years). Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression models.
Results: High parity was inversely associated with ovarian cancer, with an adjusted OR 0.43 (95% CI, 0.30 to 0.62) for women who had given birth to 3 or more children compared to women who had given no more than one birth. Ever use of oral contraceptives was also protective against ovarian cancer; adjusted OR 0.56 (95% CI, 0.40 to 0.78). No association was found for hormone replacement therapy, menopausal status, hysterectomy and family history of ovarian and/or breast cancer.
Conclusion: High parity and oral contraceptive use are associated with a lower risk of ovarian cancer in southern Chinese women.
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KEYWORD
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China, Oral contraceptives, Ovarian cancer, Parity
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